Shifts in streamflow, due to future climate and land use change, may pose risks to nearby human communities. Projecting the spatial distribution and impacts of these risks requires consideration of biophysical and socioeconomic factors. Models like the Soil and Water Assessment Tool (SWAT) can project spatial distributions of hydrologic risk due to shifting biophysical factors like climate and land use, but cannot account for socioeconomic factors influencing a community’s capacity to adapt to future streamflow changes. To address this limitation, we used a risk matrix to classify subbasins in a large river basin in the southeastern USA based on (1) percent increase in SWAT simulated 10-year and extreme high flows due to climate and land use change between baseline (1982-2002) and projected (2050-2070) periods and (2) degree of community vulnerability according to a Social Vulnerability Index (SVI). We compared spatial distributions of high risk subbasins based on SWAT results, SVI results, and the integration of SWAT and SVI results using a risk matrix. Large increases in simulated 10-year and extreme high flows occurred in middle and lower parts of the river basin and socially vulnerable communities were distributed throughout. We identified 16, 7, and 14 unique high risk subbasins using SWAT results, SVI results, and SWAT and SVI results, respectively. By using a risk matrix, we identified subbasins with vulnerable communities that are projected to experience future increases in streamflow due to climate and land use change. These results serve as a starting point for subsequent climate change adaptation planning.